ARVO2025 Recap #1 - Updates in myopia control spectacles

Authors: Xiaoqin Chen¹, Min Wu², Cui yu³, Arne Ohlendorf⁴, Wayne Li⁵, Youhua Yang⁵, Yi Zhu⁵, Lihua Li¹, Nicole Liu^4,6, Padmaja Sankaridurg^4,6

1. Optometric center, Tianjin Eye Hospital, China
2. Beijing Tongren Vision Care, Beijing Tongren Hospital, China
3. He Eye Specialist Hospital, Shenyang, Liaoning, China
4. Zeiss Vision care, Carl Zeiss Vision International GmbH, Germany
5. Zeiss Vision care, Carl Zeiss Vision (Guangzhou) Ltd., , China
6. School of Optometry and Vision Science, University of New South Wales, New South Wales, Australia

This study evaluated the myopia control efficacy of two spectacle lens designs incorporating cylindrical annular refractive elements (CARE) compared to single vision (SV) lenses over 2 years. In a double-masked, multi-centre RCT, 240 Chinese children aged 6–13 years were randomised to wear either SV, MyoCare (+4.6D CARE, 7mm central zone), or MyoCare S (+3.8D CARE, 9mm zone). After 24 months, MyoCare and MyoCare S slowed myopia progression by 0.44D and 0.40D respectively, and axial elongation by 0.20mm and 0.17mm compared to SV. Both MyoCare designs were similarly effective and showed greater benefit in older children. 

[Link to abstract]

Authors: Deborah Laughton¹, Jennifer S. Hill¹, Lucill Wang¹, Marcella McParland¹, Zhi Chen²

1. SightGlass Vision, Texas, United States
2. Shanghai EENT Hospital, Shanghai, China

12-month results were reported for a 24-month randomized controlled trial, evaluating the effectiveness of Diffusion Optics Technology (DOT) spectacle lenses in myopic Chinese children aged 6-13 (n=195). Children were assigned to wear DOT or single vision lenses, with axial length and cycloplegic refraction measured at baseline and 12 months. DOT lens wearers exhibited mean changes of 0.09mm and –0.17D, compared to 0.35mm and –0.64D in controls, representing a treatment difference of 0.26mm and 0.48D. The interim results of this ongoing trial demonstrate the myopia control effectiveness of DOT spectacle lenses in Chinese children, and builds on evidence from a previous North American study.

[Link to abstract]

Authors: Tsz Wing Leung¹^,², Carly S Y Lam¹^,², Han Yu Zhang³^,⁴, Mui Yee Kwok¹, Kenneth Liu¹^,², Fangyu Xu², Ka Mei To², Natalia Vlasak⁵

1. Centre for Myopia Research, School of Optometry, The Hong Kong Polytechnic University, Hong Kong, Hong Kong
2. Centre for Eye and Vision Research Limited, Hong Kong, Hong Kong
3. School of Medicine, Nankai University, Tianjin, China
4. Eye and Vision Science Research Institute of Nankai University, China
5. Research and Development, Hoya Vision Care, Netherlands

The myopia control effectiveness of Defocus Incorporated Multiple Segments (DIMS) spectacle lenses were evaluated in individuals who wore DIMS over 8 years versus shorter durations. Retrospective analysis of 67 participants found that those wearing DIMS lenses for 8 years (n=11) had mean myopia progression of –0.44D and axial elongation of 0.46mm, while those who wore DIMS for less than 8 years (n=55) progressed –1.44D and 0.88mm. This represented a 1.00D and 0.42mm greater reduction in the 8-year group, highlighting the long-term benefits of DIMS spectacle wear for managing myopia.

[Link to abstract]

Authors: Hsin-Yu Yang¹^,², Der-Chong Tsai²^,³

1. Department of Ophthalmology, Taipei Veterans General Hospital, Yuan-Shan and Su-Ao Branch, Yilan, Taiwan
2. Department of Ophthalmology, National Yang Ming Chiao Tung University Hospital, Yilan, Taiwan
3. School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan

9-month results were reported for a pilot study which evaluated the effectiveness of Defocus Incorporated Multiple Segments (DIMS) spectacle lenses in controlling pre-myopia in preschool children. Pre-myopic children aged 5-6 (n=24) wore plano photochromic DIMS glasses and monitored every 3 months. Over 9 months, mean SER remained stable (+0.06D/year vs. –0.15D/year in controls), axial length increased by 0.16mm, while choroidal thickness was stable. Spectacle lens adherence was high, although increased wearing time was not significantly associated with refractive or axial length changes.

[Link to abstract]

Paper: Effect of increased power and asphericity of lenslets in myopia control spectacle lenses on short-term visual performance

Authors: Bjorn Drobe¹, Soheil M. Doustkouhi¹, Ee Woon Lim¹, Si Ying Lim¹, Rajkumar Nallour Raveendran¹

1. R&D, Essilor International, affiliate of EssilorLuxottica, Singapore

[Link to abstract]

Paper: Effect of increased power and asphericity of lenslets on myopia control efficacy: 6-month interim results of a contralateral crossover clinical trial

Authors: Rajkumar Nallour Raveendran¹, Wee Sing Ong¹, Ee Woon Lim¹, Si Ying Lim¹, Hua Ren Chua¹, Bjorn Drobe¹

1. R&D, Essilor International, affiliate of EssilorLuxottica, Singapore

[Link to abstract]

Two complementary studies were conducted to evaluate the efficacy and visual performance of H.A.L.T. MAX spectacle lenses, respectively. Compared to the current H.A.L.T. spectacle lenses, H.A.L.T. MAX was developed to enhance myopia control through increased lenslet power and asphericity.

In a double-masked, contralateral, crossover randomized controlled trial involving 50 Singaporean children (mean age 8.6 years), eyes wearing H.A.L.T. MAX lenses showed slower axial length growth over 6 months compared to those wearing H.A.L.T. lenses (0.043mm vs 0.105mm), indicating improved treatment efficacy. In a separate short-term visual performance study, the high and low contrast visual acuity of H.A.L.T. and H.A.L.T. MAX lenses was compared. Results showed no significant differences between H.A.L.T. MAX and H.A.L.T. lenses for high contrast distance VA (0.11 vs 0.12 logMAR), low contrast distance VA (0.12 vs 0.14 logMAR), or low contrast near VA (0.14 vs 0.16 logMAR). The short-term findings suggest that increasing lenslet power and asphericity in H.A.L.T. MAX lenses may improve myopia control efficacy without compromising short-term visual performance.

Authors: Raffaele Parrozzani¹, Alessandro Carli¹, Carolina Molin¹, Eleonora Cosmo¹, Evelyn Longhin¹, Giulia Midena², Edoardo Midena¹^,²

1. University of Padova, Department of Ophthalmology, Padova, Italy
2. IRCCS-Fondazione Bietti, Rome, Italy

This study evaluated whether Highly Aspheric Lenslet Target (H.A.L.T) spectacle lenses could reduce myopia progression in children with myopia of prematurity (MOP) following retinopathy of prematurity (ROP). Myopia progression was compared in children with MOP who either wore H.A.L.T for 12 months (n=20) or single vision lenses for the same period (n=38). Over 12 months, the mean myopia progression was lower in the H.A.L.T. group compared to the single vision group (-0.31D vs -0.92D, respectively). The progression of myopia in children with MOP appears to be effectively slowed in patients wearing H.A.L.T. lenses, as opposed to conventional single vision lenses.

[Link to abstract]