MiSight® 1 day
Type: Contact lens - daily disposable
Material: omafilcon A 60% water hydrogel
Parameters: Base Curve 8.7mm, Diameter 14.2mm. Power range: -0.25 D* to -6.00D in 0.25 steps. Spherical powers only. (*varies by region)
Design: ActivControl® technology in MiSight® 1 day utilizes a dual-focus concentric ring design with alternating vision correction zones and treatment zones with +2.00D of defocus.
MiSight® 1 day was the first soft contact lens to be approved by the United States FDA for slowing the progression of myopia in children (see FDA indication footnote). MiSight® 1 day has a wide central vision correction zone and two treatment zones targeted to provide myopic defocus such that an approximately equivalent amount of correcting focus and myopic defocus is present regardless of pupil size.1
Myopia control mechanism
The first publication on the MiSight dual focus design was Anstice and Phillips in 2011, who described the concentric treatment zones as creating simultaneous myopic retinal defocus during both distance and near viewing.1
The newest scientific exploration of the simultaneous defocus theory in animal models has been described by world-leading researcher Earl Smith III and co-workers - read a recent publication here.
Myopia control efficacy
Two randomized controlled trials of two and three years' duration have shown efficacy in slowing axial and refractive myopia progression in children aged 8-12 years. One six-year study has indicated likely benefit in older children 11-15 years. See the scientific paper summaries below.
The MiSight fitting guide suggests first trial lens power selection based on the spherical equivalent refraction at the contact lens plane, and only adding extra minus if it improves distance vision. FDA prescribing indications (US only) are noted below.
The MiSight three year clinical trial showed that acuity outcomes were on average 6/6 or 20/20, and no different to a single vision contact lens.2
Peer reviewed science on MiSight efficacy and safety
- Ruiz-Pomeda et al 2018. MiSight Assessment Study Spain (MASS). A 2-year randomized clinical trial. [link to open access paper]
Children aged 8-12 years with myopia -0.75 to -4.00D and astigmatism <-1.00D wore MiSight or single vision (SV) spectacles as control, in a single Spanish site. After two years, average myopia progression was -0.45D vs -0.74D and 0.28mm vs 0.44mm in the MiSight and SV spectacle groups respectively, representing around a 40% control effect.
- Chamberlain et al 2019. A 3-Year Randomized Clinical Trial of MiSight Lenses for Myopia Control [link to open access paper] [link to Myopia Profile paper review]
Children aged 8-12 years with myopia -0.75 to -4.00D and astigmatism <1.00D wore MiSight or a Proclear 1 day single vision contact lens, in a multisite study in four countries. After three years, average myopia progression was -0.51D vs -1.24D and 0.30mm vs 0.62mm in the MiSight and SV contact lens groups respectively, representing around a 50-60% control effect. Distance and near acuity was similar in MiSight and SV, being 6/6 (20/20) or better throughout the study.
- Chamberlain et al 2020. Myopia Progression in Children wearing Dual-Focus Contact Lenses: 6-Year Findings [link to research abstract] [link to Myopia Profile abstract review]
Children aged 11-15 years who participated in the 3-Year MiSight study (above) either continued in MiSight or were switched from Proclear 1 day single vision contact lenses into MiSight. The new-to-MiSight group showed no significant difference in their myopia progression over the second three year period, compared to the children who had worn them for six years. This suggests a myopia controlling effect in older children fit with MiSight.
- Ruiz-Pomeda et al 2019. Binocular and accommodative function in the controlled randomised clinical trial MiSight Assessment Study Spain (MASS) [link to open access paper] [link to Myopia Profile paper review]
Measures of distance and near phoria, accommodative convergence / accommodation (AC/A) ratio, stereopsis, accommodative amplitude or accommodative response (lead/lag) were undertaken in children wearing MiSight versus single vision spectacles. Both groups showed similar results at all visits - there was no significant impact of MiSight on binocular vision function.
- Chalmers et al 2020. Adverse event rates in the retrospective cohort study of safety of paediatric soft contact lens wear: the ReCSS study. [link to open access paper] [link to Myopia Profile paper review]
Data from seven US eye care clinics was reviewed alongside that from randomized, controlled clinical trials (Ruiz-Pomeda et al 2018 and Chamberlain et al 2019 MiSight studies) for children aged 8-12 years at soft contact lens fitting. The rate of microbial keratitis was 7.4 per 10,000 years-of-wear and corneal inflammatory events 0.66% per year. This fills an important gap in understanding safety in young wearers, with rates no higher than that in adults wearing SCLs.
- Woods et al 2021. Ocular health of children wearing daily disposable contact lenses over a 6-year period. [link to open access paper]
The participants of the Chamberlain et al 2019 and 2020 studies cited above, who had worn either MiSight for six years or Proclear 1 day for three years then MiSight for three years showed no significant biomicroscopy changes compared to pre-lens wear, and no serious adverse events.
Myopia Profile relevant blog posts
Myopia Profile clinical case studies on MiSight
MiSight 1 day Professional Fitting and Information Guide (November 2019). Product description, indications, patient selection, fitting procedure, lens fit guidelines, patient instruction, wearing schedule, follow up and lens care.
CooperVision myopia information page (US page). This page provides general information for parents about vision, children’s eye exams and contact lenses for kids, myopia education, info on contact lenses, support videos and a MiSight® 1 day Overview Fact Sheet.
Brilliant FuturesTM Myopia Management Program (US page). This page explains the program to parents, which is built around the MiSight® 1 day daily disposable lenses. It includes streamlined supply as well as clinical care resources and ongoing support to simplify the process for parents.
Brilliant Futures™ with MiSight® 1 day (UK page). This page explains myopia for parents, introduces MiSight® 1 day, provides further reading, contact lens application and removal video and graphical guides, the myopia simulator to show parents and a short-sightedness assessment tool.
Welcome to MiSight® 1 day (Australasia page). This page provides general information for parents about myopia, explanation of MiSight® 1 day, further reading, contact lens application and removal video and graphical guides and the myopia simulator to show parents.
Press releases on CooperVision and myopia
- CooperVision Joins American Academy of Ophthalmology Initiative to Address Worldwide Myopia Epidemic March 22, 2021
- Special Report on Advancing Treatments for Myopia in Children Published for Healthcare Professionals March 22, 2021
- The World Council of Optometry and CooperVision Partner to Define and Promote a Standard of Care to Treat Myopia Progression March 17, 2021
- New Long-Term Study Affirms Contact Lens Wear as Healthy Option for Children March 02, 2021
- CooperVision and Essilor Partner to Accelerate Access to SightGlass Vision Technology & Expand Myopia Management Category February 03, 2021
- New Global Survey Underscores Need for Myopia Education January 27, 2021
- Largest-Ever Study on Children’s Soft Contact Lens Wear Safety Shows Very Low Complication Rates December 10, 2020
- 2020 Popular Science “Best of What’s New Awards” Recognize CooperVision MiSight® 1 Day Contact Lens Innovation December 01, 2020
- One Year After FDA Approval, MiSight® 1 Day Contact Lens Mainstreams Myopia Management in the U.S. November 16, 2020
- Following U.S. Success, CooperVision’s Brilliant Futures™ Myopia Management Program Expands Globally November 10, 2020
- CooperVision Shares Scientific Papers and Posters at BCLA UK Virtual Conference and Exhibition November 08, 2020
- CooperVision Presents Six-Year Data from MiSight® 1 Day Study; 23% of Eyes Showed No Additional Myopia Progression After Fitting October 09, 2020
- CooperVision's Brilliant Futures™ Myopia Management Program Now Reaches 45 States with 1,000+ Eye Care Practitioners Ready to Prescribe September 09, 2020
- CooperVision Announces Sarah Michelle Gellar as Spokesperson to Increase Awareness of Myopia Management and the Brilliant Futures™ Program with MiSight® 1 day Contact Lens August 26, 2020
FDA Indications for use (US only): MiSight® 1 day (omafilcon A) soft (hydrophilic) contact lenses for daily wear are indicated for the correction of myopic ametropia and for slowing the progression of myopia in children with non-diseased eyes, who at the initiation of treatment are 8-12 years of age and have a refraction of -0.75 to -4.00 diopters (spherical equivalent) with ≤0.75 diopters of astigmatism. The lens is to be discarded after each removal.
- Anstice NS, Phillips JR. Effect of dual-focus soft contact lens wear on axial myopia progression in children. Ophthalmology. 2011 Jun;118(6):1152-61. (link)
- Chamberlain P, Peixoto-de-Matos SC, Logan NS, Ngo C, Jones D, Young G. A 3-year Randomized Clinical Trial of MiSight Lenses for Myopia Control. Optom Vis Sci. 2019;96(8):556-67. (link)